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There are specific indications for the use of hydroxyurea in patients with sickle cell disease and there are certain tools to monitor its effectiveness.Hydroxyurea has been shown to be a safe medication even on long-term administration.

Examples of these drug categories include: drugs that increase Hb F production, Gardos channel inhibitors, anti-oxidants and vascular tone targeting agents (Table 2)[3,22-25].

Sickle cell disease; Sickle cell crises; Hydroxyurea; Hemoglobin S; Hemoglobin F; Adherence to treatment Sickle cell disease (SCD) is a very devastating medical condition caused by an autosomal recessive inherited hemoglobinopathy.

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