A 1985 review of antihistamine pharmacokinetics found that the elimination half-life of diphenhydramine ranged between 3.4 and 9.3 hours across five studies, with a median elimination half-life of 4.3 hours. Analogues of diphenhydramine include orphenadrine, an anticholinergic, nefopam, an analgesic, and tofenacin, an antidepressant.The selective serotonin reuptake inhibitor (SSRI) antidepressant fluoxetine is also a close analogue of diphenhydramine.The utility of diphenhydramine as an antiparkinson agent is the result of its blocking properties on the muscarinic acetylcholine receptors in the brain.
Google atrial fibrillation and you’ll find stories that warn of: “The Global Epidemic of Atrial Fibrillation,” (Circulation – Dec. Other articles warn that there is no cure for heart disease or atrial fibrillation.There are epidemics of hypertension, diabetes, high cholesterol, heart disease, migraine, anxiety, insomnia, muscle cramps – all because there is an underlying epidemic of magnesium deficiency. What mineral can do the job of treating these conditions quite nicely without any side effects? Someone recently asked me why drug companies don’t add magnesium to their drugs to counter the side effects.